Posts Tagged ‘pbc’

New Self-Care App for Primary Biliary Cholangitis (PBC)

New Self-Care App to Support Self-Management for Primary Biliary Cholangitis (PBC) The PBC Health Storylines Mobile App From Self Care Catalysts Was Developed in Collaboration With Patients, and in Partnership With the Canadian PBC Society TORONTO, ON–(Marketwired – September 09, 2016) – To celebrate International PBC Day on September 11, 2016, Self Care Catalysts —…

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Obeticholic acid reduces ALP and bilirubin in primary biliary cholangitis

Obeticholic acid reduced alkaline phosphatase and bilirubin levels in patients with primary biliary cholangitis, according to a phase 3 study published in The New England Journal of Medicine. However, patients taking the drug were more likely to experience pruritis. “The approval of obeticholic acid for primary biliary cholangitis gives us the first new drug for…

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Vanishing Bile Duct Syndrome

Vanishing Bile Duct Syndrome Description.  Vanishing bile duct syndrome (VBDS) is a rare but serious outcome and complication of drug induced liver injury marked clinically by chronic cholestasis and histologically by loss of intrahepatic bile ducts.  VBDS typically occurs after a bout of severe cholestatic hepatitis, often with immunoallergic features. Latency to Onset.  VBDS is…

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UDCA fails to improve mortality in primary biliary cholangitis

April 13, 2016 BARCELONA — The use of ursodeoxycholic acid for primary biliary cholangitis failed to reduce all-cause mortality, according to results of a systematic review presented at the International Liver Congress 2016. “Based on current evidence, the treatment of primary biliary cholangitis with ursodeoxycholic acid can neither be supported nor rejected,” Jelena Nincevic, MD,…

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Environmental Factors Tied to PBC – Acetaminophen specifically.

Environmental Factors Tied to PBC Loss of tolerance to PDC-E2 is pivotal Note: This article points the finger firmly  at acetaminophen (Tylenol or Paracetamol) as a prime cause of PBC! Action Points Primary biliary cholangitis (PBC), a chronic cholestatic liver disease, appears to begin with a loss of immune self-tolerance leading to the destruction of small-…

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