E. So, What Causes Cirrhosis?

whatE. So, What Causes Cirrhosis?

There are a number of conditions that can lead to cirrhosis:

Excessive intake of alcohol (most common)

Types B, C and D of chronic viral hepatitis,

Inherited or congenital diseases

Obesity

Hemochromatosis — abnormal accumulation of iron in the liver and other organs because of the increased absorption of iron from the intestine.

Wilson’s disease–abnormal accumulation of copper in the liver and other organs due to the decreased excretion of copper from the liver.

Alpha1-antitrypsin deficiency–inherited absence of a specific enzyme in the liver.

Glycogen storage diseases –inability to properly utilize sugars.

Autoimmune hepatitis

Prolonged obstruction or other diseases of the bile ducts (biliary cirrhosis, sclerosing cholangitis)

Prolonged exposure to environmental toxins

Some forms of heart disease (cardiac cirrhosis)

Severe reaction to drugs

Schistosomiasis (parasitic infection)

Does heavy drinking always lead to cirrhosis?

While almost everyone who drinks excessive amounts of alcohol sustains some liver damage, it does not necessarily develop into cirrhosis. In those individuals who drink one-half to one pint (8 to 16 ounces) of hard liquor per day (or the equivalent in other alcoholic drinks), for 15 years or more, about one-third develop cirrhosis. Another third develop fatty livers, while the remainder have only minor liver problems. In general, the more you drink, the greater the frequency and regularity of excessive intake, the more likely that cirrhosis is to result. A poor diet, long considered to be the main factor in the development of cirrhosis in the alcoholic, is probably only a contributing factor. Alcohol by itself, in large amounts, is a poison which can cause cirrhosis.

Can social drinkers get cirrhosis?

Some individuals who are “social drinkers,” not alcoholics, can develop cirrhosis. Factors affecting the development of cirrhosis include:
•the amount of alcohol consumed
•the regularity of intake
•natural tendency
•perhaps the state of nutrition

It is not known why some individuals are more prone to adverse reactions to alcohol than others. Women are less tolerant of alcohol than men. Researchers believe that this is because men have a greater ability than women to break down the alcohol for elimination. Studies show that a much higher percentage of women, consuming less alcohol than men, go on to cirrhosis.

Does hepatitis always result in cirrhosis?

Some patients with chronic viral hepatitis develop cirrhosis. There are five known types of viral hepatitis, each caused by a different virus.

•Acute Hepatitis A and acute Hepatitis E do not lead to chronic hepatitis.
•Acute Hepatitis B leads to chronic infection in approximately 5% of adult patients.
In a few of these patients, the chronic Hepatitis B progresses to cirrhosis.
•Acute Hepatitis D infects individuals already infected by Hepatitis B.
•Acute Hepatitis C becomes chronic in approximately 80% of adults. A minority of these patients (20-30%) will progress to cirrhosis, typically over many years.

What are the signs and symptoms of cirrhosis?

The onset of cirrhosis is often “silent” with few specific symptoms to identify what is happening in the liver. As continued scarring and destruction occur, the following signs and symptoms may appear:
•Loss of appetite
•Nausea and vomiting
•Weight loss
•Enlargement of the liver
•Jaundice–yellow discoloration of the whites of the eyes and skin occurs because bile pigment can no longer be removed by the liver
•Itching–due to the retention of bile products in the skin
•Ascites–abdominal swelling due to an accumulation of fluid caused by the obstruction of blood flow through the liver
•Vomiting of blood–frequently occurs from swollen, ruptured varices (veins that burst) in the lower end of the esophagus due to the increased pressure in these vessels caused by scar tissue formation
•Increased sensitivity to drugs–due to inability of the liver to inactivate them
•Encephalopathy (impending coma)–subtle mental changes advancing to profound confusion and coma.

The major symptoms of ascites, varices and hepatic encephalopathy have already been briefly mentioned and the following is a non-exhaustive list of what other delights may be expected:

Spidering of blood vessels
Mottling of the palm, due to altered sex hormone metabolism.
Gynecomastia. Man Boobs! Caused by hormone changes but also due to taking Spironolactone.
Loss of sex drive
Jaundice. Yellow discoloring of the skin, eye, and mucus membranes due to increased bilirubin. Urine may also appear dark.
Asterixis. Flappy hands seen in patients with hepatic encephalopathy.
Other. Weakness, fatigue, anorexia, weight loss, change of sleep patterns/day night reversal

Complications

As the disease progresses, complications may develop. In some people, these may be the first signs of the disease.
Bruising and bleeding due to decreased production of coagulation factors.
Jaundice due to decreased processing of bilirubin.
Itching (pruritus) due to bile salts products deposited in the skin.
Sensitivity to medication due to decreased metabolism of the active compounds.
Hepatocellular carcinoma is primary liver cancer, a frequent complication of cirrhosis. It has a high mortality rate.

Problems in other organs.

Cirrhosis can cause immune system dysfunction, leading to infection. Signs and symptoms of infection may be aspecific are more difficult to recognize (e.g. worsening encephalopathy but no fever).
Fluid in the abdomen (ascites) may become infected with bacteria normally present in the intestines (spontaneous bacterial peritonitis).
Hepatorenal syndrome – insufficient blood supply to the kidneys, causing acute renal failure. This complication has a very high mortality (over 50%).
Hepatopulmonary syndrome – blood bypassing the normal lung circulation (shunting), leading to cyanosis and dyspnea (shortness of breath), characteristically worse on sitting up.
Portopulmonary hypertension – increased blood pressure over the lungs as a consequence of portal hypertension.

From a purely personal point of view the other ‘minor’ symptoms that also affected me badly were inability to sleep (at night), itching, joint pain (I was one large walking ache) and spontaneous nose bleeds.

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